What's up?; What's going on?; What happened?
what's the matter?; what's going on?; how could that be?; how did that come about?; what's it all about?
how can this be?; what's to be done?; what an awful mess!
How did it happen?; What's wrong?; What went wrong?; What's up?
how?; how about?; how was it?; how are things?
what?; how?; how about?; whatever; also pr. [zen3 me5 zhe5]
Why is that?; How come?
variant of 怎麼|怎么[zen3 me5]
variant of 怎麼了|怎么了[zen3 me5 le5]